Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/5288| Title: | A practical large scale synthesis of nimesulide — A step ahead |
| Authors: | Prasad, Ashok Sharma, M L Kanwar, Seema Rathee, Raman Sharma, S D |
| Keywords: | Nimesulide;Large-scale synthesis;COX-2 selective drug |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| IPC Code: | A61P |
| Abstract: | Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selective nitration furnishes the drug (85%).
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| Page(s): | 756-760 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.64(10) [October 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 64(10) 756-760.pdf | 102.82 kB | Adobe PDF | View/Open |
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