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Title: Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf
Authors: Dey, Swarna Kamal
Middha, Sushil Kumar
Usha, Talambedu
Foudah, Ahmed Ibrahim
Ekambaram, Hemavathy
Kamala, Arunagiri
Samuel, Rosa J
Yusufoglu, Hasan Soliman
Goyal, Arvind Kumar
Keywords: Anti-diabetic;Anti-hyperglycaemia;Bambusa tulda;Glutathione peroxidase;Superoxide dismutase;Toxicity
Issue Date: Oct-2021
Publisher: CSIR-NIScPR
IPC Code: Int Cl.21: A61K 39/00, A61K 45/06, A61P 3/10, A61P 7/12, C12N 5/00
Abstract: Bambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be 6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81%) and glutathione peroxidase (31.60%) with a decline in malondialdehyde levels (21.90%) when compared to untreated alloxan-induced diabetic control rats. The histopathological assessment of pancreas also showed an increase in β-cells, though not at a significant level. Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B. tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its exact mechanism of action against diabetes.
Page(s): 920-926
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.20(4) [October 2021]

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