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http://nopr.niscpr.res.in/handle/123456789/59817| Title: | Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride |
| Authors: | Ganesh, N S Spandana, K V L D Narsaiah, A Venkat |
| Keywords: | Wittig reaction;CBS-reduction;oxidation;reductive amination;hyperparathyroidism |
| Issue Date: | May-2022 |
| Publisher: | NIScPR-CSIR, India |
| Abstract: | A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination. |
| Page(s): | 503-507 |
| ISSN: | 2583-1321 (Online); 0019-5103 (Print) |
| Appears in Collections: | IJC Vol.61(05) [May 2022] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJC 61(5) 503-507.pdf | Main Article | 3.65 MB | Adobe PDF | View/Open |
| IJC 61(5) 503-507 Suppl. Data.pdf | Supplementary Data | 301.21 kB | Adobe PDF | View/Open |
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