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http://nopr.niscpr.res.in/handle/123456789/8968| Title: | Synthesis of triphenylmethane derivative: Bisacodyl |
| Authors: | Mereyala, Hari Babu Sambaru, Kalyani |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C 15/14 |
| Abstract: | A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 oC to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde. |
| Page(s): | 615-617 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(03) [March 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(3) 615-617.pdf | 72.53 kB | Adobe PDF | View/Open |
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